I"m new to the powerstroke forums being a new owner of an 06 f250. But the old audiophile in me brought me here first. I have been installing stereos in vehicles for the past 20yrs and where there is a will and some skill, anything is possible. I just installed 2 12" polk mm1240 dvc's in my buddies 01 f350 crew cab. Both are powered be a Massive Audio N2. The rear space behind the back is literally the same. The box I made had almost 1cuft of airspace per driver. If I remember right. I have the drawing and inside measurements on a piece of paper somewhere at home. The main changes were to the rear seat brackets. Under the rear part of the seat bracket, we added about a 1" spacer and machined out the top of the bracket where the bolts go through about 5/8" to slide the seat forward. You'd have a hard time noticing the changes, the woofers dont hit the seat and it sounds pretty damn good. Hope this helps a bit.