Just a thougt from another keyboard warrior.
In the past I never ever ran fuel treatments/additives because the one time I did (stp fuel injector cleaner on a 1991 Toyota pickup with the 22re) it ran like crap that whole tank and I just went back to regular gasoline. I also never ran synthetic oils my whole life until last year lol. I feel there is some benefit particularly on the 7.3l with a fuel treatment and either a synthetic blend/full syn oil but It wasn't for lubricity or making the truck last longer or anything lol.
Fuel treatment:
I am fairly ocd, not medical diagnosis but I keep a spiral notepad in each vehicle that tracks date/miles and work/maintenance. I also have one for the house/tractor etc. I noticed running diesel kleen in the winter gave me a .5-1mpg boost like 90% of the time. I didn't notice power/idle/anything else except a very small mpg boost only on the winter fuel. Figured that was nice but I didn't do the math to see if the cost of the fuel treatment was more or less than my normal fuel cost. Also truck sits for weeks at a time so the winter fuel treatment does very well in preventing gelling etc.
Synthetic oil:
I was scared as heck to put rotella t6 5w-40 full synthetic in a 20yr old diesel because I didn't know if it would start leaking bad or if I could switch back I didn't think anything terrible would happen but I was worried about leaks. WOW was I surprised in a good way. at -25 with delo 15w-40 conventional oil my truck would whine and groan for a few minutes and was noticeably harder starting. with the 5w-40 it started up and purred like it was a sunny 80 degree day lol... Only thing I didn't like was my truck burned it fast. like 4.5quarts in 4k miles.... No oil in fuel bowl, blue, black/whit smoke, just a 20yr old diesel burning a thinner oil faster is all. I did end up going with their new t6 15w-40 full synthetic and all though its better than the conventional still not as buttery smooth in the winter as the 5w-40.
Why did I write this?
Fuel treatments help with the diesels. I am not sure its needed for engine and system survival but it helped me in the winter only (no noticeable improvement in with summer blend that I can calculate this far). I know its helped with gelling too. I had summer diesel in some older trucks and needed that diesel kleen 911 to get it started after pulling a chunky filter out lol. I use diesel kleen a few times in winter and a few times in summer especially with road trips and unknown fuel stations but not every tank at all.
Synthetic blend/full synthetic: I think it was a huge benefit especially for cold and I mean below zero cold climates but other than that no fuel economy improvements, no leaks, just about 10-20% more cost wise but worth it to me.
Now that im done listening to myself talk/type, just wanted to share what I feel was some practical experience with both.
Assuming mpg, cost and everything stays the same: foe fuel treatment cost/savings:
I fill up 99% of the time when I need 20 gallons, so assum 20 gallons at $3.00 gets me 280miles at $60 a tank at 14.0mpg
now assume most common diesel kleen cost for me that's $2 per tank giving me a 90% .5mpg boost (winter only) same above prices at 14.5mpg
if I drive 12k miles per year my cost with diesel alone is: $2571.43 annualy, with diesel kleen cost me $2565.51. So in one year I MAY SAVE: $5.92 a year.... You could probably buy the biggest container and bring it down cost wise but I only noticed a fuel boost with winter blended fuel. so its really a close call for 90% of the user as to whether it saves money.