The biggest killer of the E4OD and 4R100 is the way undersized transmission coolers. E4OD is even significantly smaller than the 4R100. The E4OD also only had a single disk converter. It wasn't until the later years of the 4R they went to a multi-disk.
A good tune will add line pressure to help hold the clutches better from slipping, causing heat.
Having a gauge or monitor is best when adding a tuner so you can keep an eye on your transmission temps.
03-10 6.0L Ford OEM 26 Row Transmission Cooler - 5C3Z7A095CA
DIRECT REPLACEMENT FOR 04-07 MODELS FITS 99-03 THAT CAME WITH SMALLER TRANSMISSION COOLERS. SOME MODIFICATIONS WILL BE REQUIRED TO TIE IN THE LINES FROM THE TRANSMISSION TO THIS COOLER. DRAMATICALLY REDUCES TRANSMISSION TEMPERATURES TO INCREASE THE LIFE OF YOUR CLUTCHES, TORQUE CONVERTER, AND...

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