I have tunes from Gearhead (unlimited tow, 8k tow, SRL+, SRLxx), quick trick (looney wild), Innovative Diesel Performance-aka IDP (XtremeX, Xtreme Race, Xtreme Street, Street, Tow), Tony Wildman aka TDP (extreme), Truck Source Diesel (Super panty dropper-aka SPD), Power Hungry Performance (100 performance, 200 extreme, 65 tow)
I have only had the SPD for a few weeks, but I can say that it is by far my favorite all around tune. Shifting is perfect to me, GH SLR+ and SLRxx are a very close second. Bottom end and midrange power is the best of all, GH and PHP are not to far behind. Top end is not quite as good as IDP XtremeX and Xtreme Race, but very close. Fuel economy is a close second to quick tricks.
For towing, PHP is my favorite, but I do not tow very often or very heavy.
Every truck responds differently to tunes and everyone has there personal likes and dislikes. The above work well for me and my truck.