2001 F350 7.3L, CrewCab, Long bed, 4x4
With my '01, in December, w/268K+ miles, I had very similar things happening. Extremely hard shift 1-2. Had to manually put it in 2nd to keep that from happening. When it would shift into over drive, the engine would rev, but no go. Had to push the OD button on the stalk to keep in 3rd. Trans had to be rebuilt. The 4R100 I have and your E4OD are very similar transmissions. Don't like being the bearer of bad news, but......