Join Date: May 2016
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I assume you're talking about the 351? The 350 is a GM engine. I suppose you can do it but you won't get the improvement you're hoping for. I've had trucks with both engines over the years and found they were quite close. The two trucks I owned with manual transmissions (1 with a 460 and 1 with a 351) were slightly better on fuel than the auto. When empty the 351 (may) have gotten 1 to 2 MPGs better than the 460 but I don't think it was ever better than that. When towing they were nearly identical because the 351 had to work so much harder.
What kind of fuel economy are you getting now? I think your money would be much better spent going through your engine and drivetrain to make sure everything is in excellent working order. Spend the rest on gas.
2007 F-350 4X4 CCSB, 6.0 PSD, ZF6 Manual Trans, 3.73s, EGR and Cat improvement, Edge CTS2 with EGT and Fuel, SCT X4, PHP FICM Programmer, Sinister Adjustable Fuel Press. Cover, Ficmrepair.com batt/alt wiring upgrade, Bosch 140 amp alternator with overdrive pulley, Rotella ELC, High-Idle mod, Mishimoto coolant filter, 6.4 starter, Genex mirror w/temp and compass, Magnum RT steps, Leer 100R Shell, Custom front bumper replacement, Steelcraft Elevation rear bumper, B&W turnover ball, 4" Cat Back exhaust, JVC head unit with backup camera, '08+ towing mirrors and rear diff. cover, etc.