I am not a fan of the big injectors in these engines if trucks a daily driver or towing machine. If you want to do 1/4 mile track or sled pulls or just making truck a toy then I see the point. The heat produced is not 6.0 friendly and those injectors are quite problematic and it matters little on what brand you buy.
That said if you are looking for more power you can do well on custom tunes 4” exhaust without cat or baffled mufflers with stock injectors. Deleting EGR system will help things too. Starting with a 190 amp or higher alt is needed to keep FICM healthy as well as the entire system
Then a full flowing 4” exhaust system with straight through packing type mufflers if you don’t like noisy exhaust. I am also a believer in the trucks fuel pump. I believe it will screw you in the buns sooner then later as both of my 2006 trucks did to me. Low fuel pressure looses power and then eats your injectors and @ $1,000.00 to have one changed it’s not worth the risk.
So I am for upgrading to either a 6.7 Pump or go with a FASS or Air Head Dog. Then you will have 55-75 psi whatever you wish all the time at every rpm.
Now I am a big advocate of installing SS o-rings in the cylinder heads on these 6.0 engines to end head gasket failures. I have not seen anyone loose their headgaskets after o-ringing on these forums. If your engine isn’t I would stay under 100 HP tunes with FICM included.
Then you get a PHP FICM tuner and you can go 25-100 HP from just fuel management. After that a SCT tuner with custom tunes from a good programmer. I did PHP custom tunes on my truck along with a ECM rollback that flashes truck back to Fords early setups that was more efficient and higher output HP 2003-2005 era.
You will of coarse need a quality turbo for it and I suggest staying with a Stage I KC Turbo 10 vane exhaust side turbine. This will flow much better off idle and even better at higher rpm’s. Don’t blow money on a Powermaxi-pad unit they just are not very good turbos, specially if you compare a Powerazz to the KC.
The turbo was upgraded by Ford in 2005 going with a 13 vane design. But the dirty secret is it was no upgrade, it was a downgrade to lower boost and HP so less engines would have head gasket failure warranty repairs. If you pull with the truck it was ok because it worked best under 2,000rpm’s.
I’m running a KC Stage I along with everything listed here along with some other things and I’m in the 450 HP range and averaging low 18’s mpg in a truck that’s almost 9,000 lbs. Best part is I have nothing to worry about in that HP range and my engine should go 400-500K.
As far as tunes I have 3 PHP Custom tunes but lot of guys use Wildman Tony and his Panty Dropper and Super Panty Dropper tune.
Okay Then, Hopefully this helps you get your head around things better. Tell us what you went with once you do get her all juiced up