How much block do you have in the rear? Does it have the OEM springs? Pro-Comp (for example) uses a 6 inch lift spring and the factory block to achieve their 6 inch lift. A 6" lift can also have an add-a-leaf and an ADDITIONAL 4" block.
Should you need to go up in the front, are there 2 holes in your track bar drop bracket? The upper on mine is for 4" and the lower is for 6". If not, then you're going to need either an adjustable track bar or a different drop bracket. Most pitman arms are for 4-6 inch lifts.
Finally, once you get your lift figured out, your tire/wheel should be fine.
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