Bought my 2012 with 134k a year and a half ago, has 160k on it now. I've had to do the AC Evap coil, and now the rad is leaking. Big deal, i'm just letting it leak until the summer.
My rig has been emissions on its whole life, and for the last 15k, DP tuned with a heavy tow tune. No issues, runs like a dream every day, gets good milage. I don't hesitate to drive it across the country and I do. I expect to see 250k-300k out of this one before I get rid of it. It'll probably give me an opportunity to put a 2015 turbo in it somewhere in the 200k range.
Fellas, the key is: don't be an idiot with the truck....Keep on top of fluids, filters, and clean fuel, and don't be an idiot on hot tunes all the time, and the engine and trans will last. Yes, you may have failure of a stock turbo on 11-14's at some point, and you may not. Same goes for the primary radiator, and the evap coil. Those are the three main, common failure points...big deal...Odds are you'll enjoy the truck for a long while before they give you an issue.
I lied. I do have issues. I just hid them so well from myself that I forgot they were issues.
1. Primary Radiator been leaking last 1500 miles - will fix this summer, leak is growing EST$1800
2. DEF sender has broken for last 6000 miles - Must keep tank above 2/3 full or CEL is triggered EST$1000 or delete
3. Evaporator core went out fall 2015 - Fixed Summer 2016 - $1300
That's all I can think of....other than that, its been pretty good. Honestly for the money sunk in these trucks these kinds of problems shouldn't be an issue, especially at only 150-160k, but that's just my opinion. My last vehicle (a chevy gasser) I put 273K on before the 4L60E took a dump and the main bearing(s) spun (5.3 vortec). All it ever had was an alternator replacement and oil changes. I never changed the tranny fluid in 273k miles. And to see more and more vehicles, even gassers, be able to attain that kind of lifespan when taken care of, kind of bumms me out when I see my truck (which was albeit bought second hand) at only 160k needing several thousand dollars sunk into it.
Other than that, it's been a real good truck all-in-all.