I DO know DPF/DOC delete + tuning out the regen. Can you run stock programming with no regen only?
What about EGR block/delete? Are the coolers as prone to leaking as the 6.0 coolers?
Oil cooler; is it as prone to clogging up as the older versions?
I think I know Job 1s had radiator/hose issues. Haven't really learned past that. Updated radiators and hoses? And when does the Job1 change to Job2?
Basically, if it's bought, it will be for a roughly 9k fifth wheel at the max. Other than that, small trailers, driving around, whatever need be. What is kind of a "need to do" list?
If possible, delete the DPF/Cat/EGR. You can do that with a stock or "No Power" tune.
A lot of guys delete the EGR with plates/plugs and replace the elbow too. Pretty cheap to do. The EGR coolers are not as prone to leaking as the 6.0, but some do leak. The EGR elbow itself gets packed with soot. You'll want to look for pictures of that... you'll probably want a new elbow. A tuner can "delete" the EGR, but it doesn't stop the flow of coolant.
Oil cooler, also not as big an issue.
Replace Ford Gold coolant with something else and add a coolant filter.
Change oil and fuel filters often (5k and 10k respectively). Drain the water separator monthly or every 3-4 tankfuls (whichever is sooner).
Job 2's were around August or September I think. Most trucks should have the fixes in place by now. If not, get them done. The radiators are still hit or miss regardless if they've been replaced or not. Later trucks seem to have less issues though.
If you run big power tunes, you'll probably want to get headstuds done. That's a judgement call. You'll probably know how you'll treat it.
Change trans fluid regularly. The same with rear end (and front end) and transfer case (if applicable).
You may need an upgraded air filter if you run larger HP tunes.
Add a cetane booster plus something for fuel lubricity. There are many products out there that accomplish this.
Check your brake fluid and power steering fluid regularly.