Help diagnosing #5 cylinder misfire

[Piratejonh]

Can anyone walk me through a diagnost for as #5 cylinder misfire?

I'm helping a friend. He has a 2006 Ford F250 Triton 5.4 L engine.

HX:Truck idiling poorly/riding rough intermittently. Worse under load. black smoke gasoline smell from tailpipe
#5 cylinder misfire code.
Pulled the Coil from #5 and switched it with #1
also replace the #5 plug with oem replacement. The one pulled was dry carbon coated, but otherwise OK.
Cleared codes, drove 25 miles, Cylinder 5 misfire again.
Now what? Seems to me that if I can smell fuel then the injector is working??

[LOVEMYTRUCK]

HI,I do not know if this is relevant or not but years ago we had a 1988
f-250 with a 460 cu. in engine that would not start finally found out it was the fuel pressure regulator it would flood the engine.

[toad]

First compression check.