Yes, you could pull that pipe and block off the exhaust flow thru the EGR cooler. This will help keep the cooler from blowing because it will no longer be trying to cool hot exhaust. It will also keep it from plugging up the intake with soot. You can pull that pipe off going to the EGR cooler and install a freeze plug. I forget the exact size of the freeze plug but it was a rather common size that Napa had in stock.
If for some reason the EGR cooler does still rupture it will still be able to push coolant into the intake, seeing as that side won't be blocked off. But the chances of it rupturing should be very low if it's blocked off.
Now for the bad news. 06 up vehicles will throw a check engine light if the EGR cooler is deleted/not flowing. It won't throw the light right away, but eventually the PCM is going to realize there is no EGR flow and log a code turning on the CEL. The only way to get around this is to install a aftermarket tuner that disables the EGR function in the PCM. Something along the lines of a SCT SF3 tuner. I do alot of deletes for landscapers with 450/550 trucks and I always have to install a tuner on the later years trucks. I just put it on the lowest 50hp setting and haven't had any issues.
Crappy thing for you is now your cheap EGR delete is going to require a $400 tuner.....
I'd still try and do the deletes, or you can try and go with something like a bulletproof diesel EGR cooler. They are much tougher and have a lifetime warranty.
Also, most EGR coolers are due to plugged oil coolers. The coolant flow for the EGR cooler goes thru the oil cooler first, then to the EGR cooler. The oil cooler has very fine passageways that get clogged up, causing low coolant flow to the EGR cooler. This makes the coolant in the EGR cooler actually start to boil, which causes excessive coolant pressures and eventually the cooler ruptures.
Here's a good article on 6.0 issues from bulletproofs website.
Do some reading up on these engines and it will save you in the long run. Neglect them and they will bite you in the butt.
Oh, and welcome to the forum!