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Most of how well these vans run is dependent on how well they have been taken care of just like any other vehical.
Production changes on van engines and transmissions are almost identical to the trucks, with the exception of the turbo, programming, and of course no intercooler.
The "split shot" injectors on 99+ engines are quieter and more EPA friendly but aren't really better at fuel milage, as far as I know at least.
All depending on the quality of the fuel and oil, injectors and the HPOP that drives the injectors, seem to last around 250,000-300,000 miles from what I have read.
You also cannot expect to get 60mpg with these vans, as they have almost 4x the weight of VWs. Fully loaded, expect to get around 10-14mpg in the city and 14-18 highway, all depending on the gearing and your foot.
2001 Ford E350 7.3 Extended Cargo Van
BTS Transmission, PHP Minotaur package, 4" exhaust/downpipe, Honey Badger jr., FRX, HPX, AIH delete, Fuel bowl mod, Hypermax Boost/Pyro gauge, 4.10 rear.