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i have a 2000 7.3 with a 6 speed, and i have a very similar combo. i have the 38R, an AFE intake, Snow Perf water/meth inj, dp tuner 6 pos chip, 4" turbo back, cfm manifold, 160cc/100% injectors and just installed the Turbo Master today, which is an awesome upgrade by the way. I have an Adrenaline HPOP, a 203* thermostat and a Mishimoto Intercooler sitting next to me that i didnt get around to doing today and i think its a pretty good combo, the truck gets up and goes and i have 37" tires on it. it was running pretty dirty on the highest tune before i put the Turbo Master on but now the boost picks up so quick i cant even floor it, it really is an incredible little upgrade.
A couple words of advice though, if you can find it there is a lubricant that is called "freeze off" i think, that will pop you stock exhaust clamps off on their own, all you have to do is loosen the bolt you dont even have to do much prying. Also put the turbo master on before you put it in the truck, i shredded my hands trying to shove it all the way back there to change that out. and with the FRX make sure you soak those things in wd 40 or something, they are stubborn, and try to find that socket for those things too, i forget what size it is but its a 6 point, works the best but if you cant find it vise grips can pull off the job too.
And i havent had a single problem with all of it, what size injectors are you running or plannins on running?
2000 F250 CCSB 7.3 PSD 6 Speed CFM Intake Manifold AFM Stage 2 Intake Snow Performance Water/Methanol Injection 160/100 Injectors GTP38R Adrenaline HPOP 203* Thermostat Air Dog II Gear Vendors Over/Underddrive 450HP Clutch 4.88 Gears ARB Lockers Mishimoto Intercooler Turbomaster Wastegate Controller 4" Turbo Back Exhaust DP Tuner Icon 4" Lift 37" Procomp Mud Terrains Fabtech Tration Bars