If your reloading race tunes, I would do the relearn process that Spartan has posted on their forum and in the TCM instructions. If you reload to a lower tune, then you really don't need to do a specified relearn. The race tunes do need the relearn process. I would do it on the 210 and up tunes.
Here is the process Spartan has....
1.) From a stop, accelerate the vehicle to 55-60 mph at approximately 1/4 throttle. DO THIS TWICE.
2.) From a stop, accelerate the vehicle to 65-70 mph at approximately 1/2 throttle. DO THIS TWICE.
3.) From a stop, accelerate the vehicle to 70 mph at approximately 3/4 throttle. DO THIS TWICE.
4.) From a 40 mph roll, press the accelerator to the floorboard quickly (forcing the truck to downshift) and accelerate to around 75 mph.
5.) From a stop, acclerate to 75 mph at wide open throttle (press the accelator to the floor immediately). DO THIS 2-3 TIMES.