Most people will find one file that they like and run that file all the time. It could be an economy, tow, street, performance or anything in between tune.
We, for instance, have different settings for different applications.
Our economy is designed for stop and go traffic where it reduces turbo lag.
Our tow of course is for pulling and plows.
Our street is for highway driving and is very economical on long trips.
Our Looney is a city file/show-off file/race file and track file depending on the level of power.
Then we have a street smoke for people who want to play and a transmission only that serves to be used with another programmer at zero power level, for the gauges or to tow very heavy.
As far as which is more economical, that is for you and your truck to decide.
That's the beauty of custom tuning that you can more or less, get what you are looking for with just a tweak