Engine unresponsive after release of aggressive acceleration

[jwcarp01]

Vehicle Background: 2005 F250 6.0. Just turned 100 K miles. I'm new to the powerstroke world, my father purchased the truck new, he passed recently, and I've inherited it. Its always been driven easy, but not sure how well he maintained the vehicle. Over the past 30 days, I've changed the oil, both fuel filters, cleaned EGR valve and replaced O-rings, and changed the air-filter. I plan to change the rest of the fluids (tranny, front-end, rear-end, etc) over the next few weeks.
Problem: After an aggressive acceleration, releasing the throttle, then re-accelerating, the truck doesn't respond to the acceleration. I noticed this the first time after cruising, passing a vehicle using WOT, then letting off to slow down for a curve, then re-applying after rounding the curve. The truck didn't respond to the acceleration at all the way it should've. The engine began missing, smoke was pouring out of the exhaust, until I was able to coast into a parking lot. I turned truck off, and checked my fluids, which were all as they should be. After a few minutes, I started the truck back up and it ran as if nothing was wrong. This is when I decided to clean the EGR valve. After cleaning, I thought I would give the truck a try again. To my dismay, it was the same outcome. I've searched several forum topics, and no one has seemed to have the problem I've had or described symptoms such as these. As long as the acceleration is gradual (Sunday driving), the truck runs perfectly. Once the right foot gets a little heavy, everything goes to S***, momentarily. Any suggestions would be greatly appreciated.

[MN6.0f250]

If I were you, I would take it to the dealer and have them do a cylinder performance check, just a guess, but I would say it could be a sticking injector, at 100k wouldn't surprise me to see some injector issues. Being that you are new to the 6.0 world, just so you know they are great motors if you do your maintenance on them, that and a lot of problems start to develop around the 100k mark, but once you work through them you will have a great truck. A lot of the problems that guys complain about these engines are because they either didn't take care of them, or that they put their tuners on them and cranked the power up and blew their head gaskets (which are already known to have problems)