Innovative Diesel's Xtreme Race and DJ's Looney Tune are probably the "safest" high power tunes out there. I say "safest", because anything can break, even stock.
A tuner can really crank it up, but a non heavily modded truck probably wouldn't last 500 miles.
If you like the Looney, cool. Do the studs, intake, upgrade the turbo, consider water/meth and/or N2O... Then have them tweek your tune to match.